Nation More than 107,000 Americans died from overdoses last year. This drug is behind most deaths. May 11, 2022May 11, 2022Ken Alltucker, USA TODAYComments Off on More than 107,000 Americans died from overdoses last year. This drug is behind most deaths. While prescription painkillers and heroin drove an overdose epidemic last decade, the powerful synthetic opioid fentanyl now causes most drug deaths.